Reduction of oxygen after cardiac arrest: The EXACT trial

Funding: 2015 NHMRC Project grant application – successfully funded

Contact Investigator: Professor Steve Bernard

We aim to conduct a Phase 3 multi-centre, randomised, controlled trial to determine whether reducing oxygen administration to target a normal level as soon as possible following successful resuscitation from out-of-hospital cardiac arrest, compared to current practice of maintaining 100% oxygen, improves patient survival at hospital discharge.


Developing a community-based CPR education program

Funding: National Heart Foundation; $75,000

Contact Investigator: Dr Janet Bray

Dr Janet Bray, Dr Lahn Straney, Associate Professor Karen Smith and Professor Judith Finn have been awarded a $75,000 Heart Foundation Vanguard Grant to develop community-based cardiopulmonary resuscitation (CPR) education programs. Their application to the Heart Foundation also won them the Ross Hohnen Award for Research Excellence for the most outstanding and innovative Vanguard Grant application, providing an extra $10,000 on top of the grant. The grant will be used to understand why bystander CPR rates are low in specific regions of Victoria, Such information will be used to inform the design and development of an intervention which the researchers hope to conduct and evaluate with future funding.


Post-resuscitation care in Victoria: understanding current practice to improve outcomes for OHCA patients.

Funding: Nurses Board of Victoria Legacy Limited ($50,000)

Dr Janet Bray, Dr Lahn Straney, Associate Professor Karen Smith, Professor Stephen Bernard, Dr Dion Stub  and Professor Judith Finn have been awarded $50,000 to conduct an audit of post-arrest care across Victorian Hospitals. Dr Bray also awarded $10,000 from the Ian Jacob’s Fellowship (Australian Resuscitation Council) to extend the audit to smaller regional hospitals.


 The RINSE Study

Funding: NHMRC Project Grant 2011-2015; $677,888

Contact Investigator: Professor Steve Bernard

The Rapid Infusion of Cold Normal Saline (RINSE) study is a randomised controlled trial, to determine whether paramedic initiated cooling during CPR (using a rapid intravenous infusion of ice-cold normal saline) improves patient survival outcomes compared with usual practice in patients who are being resuscitated from out-of-hospital cardiac arrest.